Nephrotoxicity induced by long-term oral administration of different doses of chlorpyrifos.

Abstract

Wistar rats (male) were divided into 3 groups - group A (GA) served as control, group B (GB) were daily administered chlorpyrifos (Anu Products Ltd., India) orally at a dose of 5 mg/kg b wt. and animals in group C (GC) received daily an oral administration of chlorpyrifos at a dose of 10 mg/kg b wt. Rats were sacrificed on 1st, 2nd, 4th, 6th and 8th week after initiation of the experiment. Kidneys were extirpated and fixed in aqueous Bouin's solution. The tissues thus fixed were routinely processed for histological studies. The present study showed that the histopathological changes were caused in kidney of rats by chlorpyrifos administration. The changes noticed were mainly the shrinkage of glomerulus at initial stage of treatment, the tubular dilation, the glomerular hypercellularity, hypertrophy of tubular epithelium, degeneration of glomerulus and renal tubules, deposition of eosin-positive substances in the glomerulus and renal tubules and infiltration of leucocytes. A decrease in the body weight gain was observed in chlorpyrifos-treated rats. However, variable intensities of these changes were noticed depending upon the doses and duration of the treatment.

• Authors: Sarojni Tripathi, Ajai Kumar Srivastav
• Journal: Toxicology and industrial health (Toxicol Ind Health) Vol. 26 Issue 7 Pg. 439-47 (Aug 2010) ISSN: 1477-0393 [Electronic] England
• PMID: 20504822 (Publication Type: Journal Article)

Chemical References

• Insecticides
• Chlorpyrifos
• Eosine Yellowish-(YS)

Topics

• Administration, Oral
• Animals
• Chlorpyrifos (toxicity)
• Dose-Response Relationship, Drug
• Eosine Yellowish-(YS) (metabolism)
• Histocytochemistry
• Insecticides (toxicity)
• Kidney Diseases (chemically induced, metabolism)
• Kidney Glomerulus (drug effects)
• Kidney Tubules (drug effects)
• Male
• Rats
• Rats, Wistar
• Toxicity Tests, Chronic (methods)
• Weight Loss (drug effects)