We report a case of giant advanced
breast cancer with skin ulceration and
bleeding (T4cN3M0, Stage IIIC) in which a significant QOL improvement was achieved with
epirubicin and
cyclophosphamide (EC) followed by weekly
paclitaxel. A 63- year-old postmenopausal woman presented in May 2008 with a giant ulcerated right
breast tumor and extensive
erythema of the involved skin. She had discovered the
tumor the previous year, but had not sought medical advice or treatment. A core needle biopsy of the breast mass led to a diagnosis of an invasive
ductal carcinoma negative for
estrogen receptor, progester-one receptor, and HER2/neu
protein expression. She received q3w 4 cycles of EC(E: 60 mg/m(2), C: 600 mg/m(2))and 12 cycles of weekly
paclitaxel (80 mg/m(2)). Upon completion of this
chemotherapy, the
breast tumor and skin
erythema had nearly disappeared. A
mastectomy was then performed with partial resection of the muscle and axillary
lymph node dissection. Pathological examination showed only focal
residual tumor cells and complete disappearance of
cancer cells in the lymph nodes (Grade 2). EC followed by weekly
paclitaxel therapy was effective for the locally advanced ulcerative
breast tumor, and significantly improved QOL in this patient with Stage III C advanced
breast cancer.