Anakinra's efficacy is variable in refractory gout: report of ten cases.

Abstract

OBJECTIVES:

To evaluate the efficacy of anakinra for patients with acute gout.

METHODS:

We reviewed the charts of 10 patients who received anakinra for urate crystal-induced arthritis at the Hospital for Special Surgery since 2007. Demographic information, comorbidities, short-term treatment outcomes, and subsequent flares were reviewed.

RESULTS:

Patients in our study had a high prevalence of comorbidities. All patients received corticosteroids before anakinra treatment. The mean number of anakinra injections was 3.2 per patient (100 mg subcutaneously per day). Six patients had a good response. Three patients had a partial response and 1 patient had no response. Nine patients had documented recurrent flares after discontinuing anakinra (ranging from 3 to 45 days after).

CONCLUSION:

Anakinra is a therapeutic option for patients with acute urate crystal-induced arthritis who do not respond to or have a contraindication to traditional treatments. Although a short course of anakinra resulted in favorable outcomes for some of our patients, response rates were poorer in our study than in previously published reports, and relapses were common.

• Authors: Kun Chen, Theodore Fields, Carol A Mancuso, Anne R Bass, Lisa Vasanth
• Journal: Seminars in arthritis and rheumatism (Semin Arthritis Rheum) Vol. 40 Issue 3 Pg. 210-4 (Dec 2010) ISSN: 1532-866X [Electronic] United States
• PMID: 20494407 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2010. Published by Elsevier Inc.

Chemical References

• Antirheumatic Agents
• Interleukin 1 Receptor Antagonist Protein

Topics

• Adult
• Aged
• Aged, 80 and over
• Antirheumatic Agents (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Female
• Gout (drug therapy)
• Humans
• Injections, Subcutaneous
• Interleukin 1 Receptor Antagonist Protein (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Retrospective Studies
• Treatment Outcome