Abstract |
The results of the use of ozonised sunflower oil (OLEOZON(®)) in the treatment of onychomycosis, based on its known antimycotic action and good skin tolerance, by means of a controlled randomised phase III assay are presented. A total of 400 outpatients were randomly divided into two groups: experimental, treated with topical OLEOZON(®), two times per day and control, treated also two times per day, with ketoconazole cream 2%, for 3 months. A patient was considered cured when the sick nails regained the normal colour, growth and thickness, with a negative mycological study. In the experimental group, a regression of signs was achieved from the first month of treatment, while in the control group, it was obtained after the third month of treatment. All patients treated with OLEOZON(®) had improvement in their condition (9.5%) or were cured (90.5%). However, in the control group, only 13.5% of patients were cured, 27.5% improved and 59% remained the same, with significant differences between both the groups. After 1 year of follow-up, experimental and control groups presented 2.8% and 44.4% of relapses, respectively. Topical OLEOZON(®) demonstrated effectiveness in the treatment of onychomycosis, superior to that of ketoconazole. No side effects were observed.
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Authors | Silvia Menéndez, Leopoldina Falcón, Yordana Maqueira |
Journal | Mycoses
(Mycoses)
Vol. 54
Issue 5
Pg. e272-7
(Sep 2011)
ISSN: 1439-0507 [Electronic] Germany |
PMID | 20492527
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2010 Blackwell Verlag GmbH. |
Chemical References |
- Antifungal Agents
- Plant Oils
- Sunflower Oil
- Ketoconazole
|
Topics |
- Administration, Topical
- Adult
- Aged
- Antifungal Agents
(administration & dosage)
- Female
- Humans
- Ketoconazole
(administration & dosage)
- Male
- Middle Aged
- Nails
(pathology)
- Onychomycosis
(drug therapy)
- Plant Oils
(administration & dosage)
- Sunflower Oil
- Treatment Outcome
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