Antifungal therapies in murine disseminated phaeohyphomycoses caused by Exophiala species.

Abstract

OBJECTIVES:

We have evaluated the efficacy of posaconazole, itraconazole and amphotericin B in murine models of disseminated infection caused by Exophiala spp.

METHODS:

Immunosuppressed mice were treated with posaconazole at 10, 20 or 40 mg/kg/day orally (po), amphotericin B at 1.5 mg/kg/day intraperitoneally (ip) or itraconazole at 50 mg/kg/day po. Treatment began 1 day after infection and continued for 7 days post-infection. Two strains of each of the three most relevant clinical species, i.e. Exophiala dermatitidis, Exophiala oligosperma and Exophiala xenobiotica, were tested.

RESULTS:

Posaconazole showed the highest efficacy in mice infected with E. dermatitidis, the only species that showed a high neurotropism, while the three drugs showed a similarly good activity against E. oligosperma and E. xenobiotica infections.

CONCLUSIONS:

The results suggest that posaconazole may have a clinical role in the treatment of disseminated infections caused by Exophiala species, especially in those with CNS invasion.

• Authors: Enrique Calvo, F Javier Pastor, Josep Guarro
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 65 Issue 7 Pg. 1455-9 (Jul 2010) ISSN: 1460-2091 [Electronic] England
• PMID: 20488983 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Triazoles
• Itraconazole
• posaconazole
• Amphotericin B

Topics

• Administration, Oral
• Amphotericin B (administration & dosage)
• Animals
• Antifungal Agents (administration & dosage)
• Exophiala (drug effects, isolation & purification)
• Injections, Intraperitoneal
• Itraconazole (administration & dosage)
• Male
• Mice
• Mycoses (drug therapy, microbiology)
• Treatment Outcome
• Triazoles (administration & dosage)