Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: The aerial parts of Equisetum palustre L. are used to treat peptic ulcer disease in Turkey. In a previous study, a flavonol diglucoside i.e., kaempferol 3-O-1''-beta-D-glucopyranosyl-3-O-1'''-beta-D-glucopyranoside (KGG) was isolated as the major antiulcerogenic constituent from the plant. AIM OF THE STUDY: The present study was undertaken to evaluate the antiulcer activity profile of KGG using various in vivo experimental ulcer models as well as by assessing gastric biochemical parameters. MATERIAL AND METHODS: KGG was obtained from the ethanol extract of the aerial parts of the plant by successive chromatographical methods. The activity profile of the compound was investigated using several ulcerogenesis models such as indomethacin-, indomethacin plus HCl/EtOH-, cysteamine-, serotonin-, N(G)-nitro-L-arginine methyl ester plus EtOH-, diethyldithiocarbamate-, N-ethylmaleimide plus EtOH-, water immersion and restraint stress-, pyloric ligation-induced ulcers. In addition, effects of KGG on the biochemical parameters of gastric juice; i.e., inhibition of titratable gastric acidity, acid output, gastric pH, gastric secretion volume and peptic activity were studied. RESULTS: CONCLUSION: Results of this investigation have clearly demonstrated that KGG was found to improve the cytoprotective mechanisms of the gastric mucosa. On the other hand, a weak activity profile was observed on the parameters affecting the gastric acidity (water immersion and restraint-induced-, pyloric ligation-induced-ulcerogenesis and titratable acidity).
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Authors | Erdem Yesilada, Ilhan Gurbuz |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 131
Issue 1
Pg. 17-21
(Aug 19 2010)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 20488236
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Anti-Ulcer Agents
- Flavonols
- Glucosides
- Plant Extracts
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Topics |
- Animals
- Anti-Ulcer Agents
(isolation & purification, pharmacology, therapeutic use)
- Drug Evaluation, Preclinical
(methods)
- Equisetum
- Female
- Flavonols
(isolation & purification, pharmacology, therapeutic use)
- Gastric Mucosa
(drug effects, pathology)
- Glucosides
(isolation & purification, pharmacology, therapeutic use)
- Male
- Mice
- Plant Components, Aerial
- Plant Extracts
(isolation & purification, pharmacology, therapeutic use)
- Rats
- Rats, Sprague-Dawley
- Stomach Ulcer
(pathology, prevention & control)
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