Abstract | BACKGROUND/AIMS: Several simple tests for hepatic fibrosis employ indirect markers. However, the efficacy of using direct and indirect serum markers to predict significant fibrosis in clinical practice is inconclusive. We analyzed the efficacy of a previously reported indirect marker of hepatic fibrosis - the aspartate aminotransferase to platelet ratio index (APRI) - in patients with nonalcoholic chronic liver diseases ( CLDs). METHODS: RESULTS: The mean area under the receiver operating characteristic curve (AUROC) of APRI for predicting significant fibrosis in nonalcoholic CLDs was 0.84 [95% confidence interval (CI), 0.78-0.91]. APRI yielded the highest mean AUROC in the patients with chronic hepatitis B (0.85; 95% CI, 0.771-0.926). The positive predictive value of APRI >/=1.5 for predicting significant fibrosis was 89%. The negative predictive value of APRI <0.5 for excluding significant fibrosis was 80%. CONCLUSIONS: APRI might be a simple and noninvasive index for predicting significant fibrosis in nonalcoholic CLDs.
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Authors | Woon Geon Shin, Sang Hoon Park, Sun-Young Jun, Jae One Jung, Joon Ho Moon, Jong Pyo Kim, Kyoung Oh Kim, Cheol Hee Park, Tai Ho Hahn, Kyo-Sang Yoo, Jong Hyeok Kim, Choong Kee Park |
Journal | Gut and liver
(Gut Liver)
Vol. 1
Issue 2
Pg. 145-50
(Dec 2007)
ISSN: 2005-1212 [Electronic] Korea (South) |
PMID | 20485631
(Publication Type: Journal Article)
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