Abstract | BACKGROUND: An enhanced sebaceous gland activity with production of proinflammtory sebaceous lipids belongs to the major pathogenetic factors of acne. Hormonal antiandrogen treatment targets the androgen-metabolizing cells of the pilosebaceous unit, i. e. follicular kertinocytes and sebocytes, and leads to sebostasis, with a reduction of the sebum secretion rate of 12.5 to 65 %. Concerning their mechanism of action, hormonal antiandrogens are classified in androgen receptor blockers, inhibitors of circulating androgens by affecting the ovarial function ( oral contraceptives), inhibitors of circulating androgens by affecting the pituitary (gonadotrophin-releasing hormone agonists and dopamin agonists in hyperprolactinemia), inhibitors of the adrenal function, and inhibitors of peripheral androgen metabolism (5- reductase inhibitors, inhibitors of other enzymes). METHODS: In this study, all original and review publications on hormonal antiandrogen treatment of acne as monotherapy or in combination included in MEDLINE, EMBASE and COCHRANE libraries were extracted by using the terms " acne", " seborrhea", " polycystic ovary syndrome", "hyperandrog*" and "treatment" and classified according to their level of evidence. RESULTS: CONCLUSIONS:
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Authors | Christos C Zouboulis, Thomas Rabe |
Journal | Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
(J Dtsch Dermatol Ges)
Vol. 8 Suppl 1
Pg. S60-74
(Mar 2010)
ISSN: 1610-0387 [Electronic] Germany |
Vernacular Title | Hormonelle Antiandrogene in der Aknetherapie. |
PMID | 20482693
(Publication Type: Comparative Study, Journal Article, Review)
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Chemical References |
- Androgen Antagonists
- Contraceptives, Oral, Hormonal
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Topics |
- Acne Vulgaris
(drug therapy)
- Algorithms
- Androgen Antagonists
(therapeutic use)
- Contraceptives, Oral, Hormonal
(therapeutic use)
- Drug Therapy, Combination
- Evidence-Based Medicine
- Female
- Humans
- Hyperandrogenism
(drug therapy, etiology)
- Sebum
(drug effects, metabolism)
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