Effect of prothrombin 19911 A>G polymorphism on the risk of cerebral sinus-venous thrombosis.

Abstract

BACKGROUND AND PURPOSE:

The A>G polymorphism at position 19911 of the prothrombin gene is associated with a mildly increased risk of venous thromboembolism, alone or in association with such common thrombophilia mutations as factor V Leiden and prothrombin 20210 GA. Its role in cerebral sinus-venous thrombosis (CSVT) is not known.

METHODS:

The presence of prothrombin 19911 A>G was investigated in a case–control study of 107 patients with cerebral thrombosis and factor V Leiden (n = 25), prothrombin 20210 GA (n = 47), without known thrombophilia (n = 35) and 842 healthy individuals with the corresponding coagulation profile.

RESULTS:

Prothrombin 19911 A>G did not increase the risk of CSVT in carriers of factor V Leiden (adjusted odds ratio 1.6, 95%CI 0.6–4.7), prothrombin 20210 GA (odds ratio 1.1, 95%CI 0.6–2.2), nor in patients without known thrombophilia (odds ratio 1.3, 95%CI 0.5–3.1).

CONCLUSIONS:

Prothrombin 19911 A>G polymorphism does not appear to be a risk factor for CSVT, alone or in association with factor V Leiden or prothrombin 20210GA.

• Authors: I Martinelli, P Bucciarelli, V De Stefano, S M Passamonti, M Menegatti, D Tormene, A Tosetto, P M Mannucci
• Journal: European journal of neurology (Eur J Neurol) Vol. 17 Issue 12 Pg. 1482-5 (Dec 2010) ISSN: 1468-1331 [Electronic] England
• PMID: 20482605 (Publication Type: Journal Article)
• Copyright: © 2010 The Author(s). European Journal of Neurology © 2010 EFNS.

Chemical References

• factor V Leiden
• Factor V
• Prothrombin

Topics

• Adolescent
• Adult
• Aged
• Case-Control Studies
• Child
• Child, Preschool
• Factor V (genetics)
• Female
• Genetic Predisposition to Disease
• Humans
• Infant
• Male
• Middle Aged
• Polymorphism, Genetic
• Prothrombin (genetics)
• Sinus Thrombosis, Intracranial (genetics)
• Thrombophilia (genetics)