Abstract |
The antagonistic effect of chlorophyllin was tested in reducing the clastogenic action of cesium chloride ( CsCl) in vivo on mice bone marrow cells. CsCl induced chromosomal aberration in frequencies directly proportional to the dose administered. Chlorophyllin, when given alone, was not clastogenic even at a concentration of 1.5 mg/kg body wt. of the animal. Simultaneous administration of chlorophyllin and CsCl reduced chromosomal aberrations significantly at 24 h. Exposure to the same dose of chlorophyllin 2 h before exposure to CsCl also decreased clastogenic effects but to a lesser extent. These findings are of importance in view of the uptake of radioactive Cs by green plants after nuclear fallout.
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Authors | A Ghosh, S Sen, A Sharma, G Talukder |
Journal | Toxicology letters
(Toxicol Lett)
Vol. 57
Issue 1
Pg. 11-7
(Jun 1991)
ISSN: 0378-4274 [Print] Netherlands |
PMID | 2048156
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chlorides
- Chlorophyllides
- Mutagens
- Cesium
- chlorophyllin
- cesium chloride
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Topics |
- Animals
- Bone Marrow
(drug effects, ultrastructure)
- Cesium
(antagonists & inhibitors, toxicity)
- Chlorides
- Chlorophyllides
(administration & dosage, pharmacology)
- Chromosome Aberrations
- Dose-Response Relationship, Drug
- Environmental Exposure
- Female
- Mice
- Mitotic Index
(drug effects)
- Mutagens
(antagonists & inhibitors)
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