Vaccinia virus: a tool for research and vaccine development.

Abstract

Vaccinia virus is no longer needed for smallpox immunization, but now serves as a useful vector for expressing genes within the cytoplasm of eukaryotic cells. As a research tool, recombinant vaccinia viruses are used to synthesize biologically active proteins and analyze structure-function relations, determine the targets of humoral- and cell-mediated immunity, and investigate the immune responses needed for protection against specific infectious diseases. When more data on safety and efficacy are available, recombinant vaccinia and related poxviruses may be candidates for live vaccines and for cancer immunotherapy.

• Authors: B Moss
• Journal: Science (New York, N.Y.) (Science) Vol. 252 Issue 5013 Pg. 1662-7 (Jun 21 1991) ISSN: 0036-8075 [Print] United States
• PMID: 2047875 (Publication Type: Journal Article, Review)

Chemical References

• Recombinant Proteins
• Vaccines, Synthetic

Topics

• Animals
• Bacteriophages (genetics)
• Gene Expression
• Genetic Engineering (methods)
• Genetic Vectors
• Humans
• Recombinant Proteins
• Vaccines, Synthetic
• Vaccinia virus (genetics, immunology)