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Tooth discoloration of immature permanent incisor associated with triple antibiotic therapy: a case report.

AbstractINTRODUCTION:
A triple antibiotic mixture of ciprofloxacin, metronidazole, and minocycline was used as an intracanal medicament in an attempt to disinfect the root canal system for revascularization of a tooth with a necrotic pulp. However, discoloration developed after applying the triple antibiotic mixture.
METHODS:
Six weeks after a triple antibiotic paste had been applied to the root canal of tooth #8 of a 7-year-old girl, the tooth showed a dark discoloration. An in vitro experiment with human extracted teeth was performed to determine which of the 3 antibiotics caused the tooth discoloration. Another experiment was then carried out to examine whether a currently used dentin bonding agent would prevent or reduce such discoloration. The degree of discoloration was assessed by using a colorimeter.
RESULTS:
Among the components of the triple antibiotic paste, only minocycline caused the tooth discoloration. Moreover, the dentin bonding agent reduced the intensity of the discoloration but did not prevent it.
CONCLUSIONS:
The possible esthetic problems with the tooth color should be considered when using minocycline as a canal medication.
AuthorsJong-Hyun Kim, Yuran Kim, Su-Jung Shin, Jeong-Won Park, Il-Young Jung
JournalJournal of endodontics (J Endod) Vol. 36 Issue 6 Pg. 1086-91 (Jun 2010) ISSN: 1878-3554 [Electronic] United States
PMID20478471 (Publication Type: Case Reports, Comparative Study, Journal Article, Randomized Controlled Trial)
CopyrightCopyright 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Acrylic Resins
  • AdheSE cement
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Dental Disinfectants
  • Dentin-Bonding Agents
  • Drug Combinations
  • Root Canal Irrigants
  • Metronidazole
  • Ciprofloxacin
  • Minocycline
Topics
  • Acrylic Resins (chemistry)
  • Anti-Bacterial Agents (adverse effects)
  • Anti-Infective Agents (therapeutic use)
  • Child
  • Ciprofloxacin (therapeutic use)
  • Colorimetry
  • Dental Disinfectants (adverse effects)
  • Dental Pulp Necrosis (drug therapy, therapy)
  • Dentin-Bonding Agents (chemistry)
  • Drug Combinations
  • Female
  • Follow-Up Studies
  • Humans
  • Incisor (drug effects)
  • Metronidazole (therapeutic use)
  • Minocycline (adverse effects)
  • Periapical Periodontitis (drug therapy, therapy)
  • Root Canal Irrigants (adverse effects)
  • Tooth Bleaching (methods)
  • Tooth Crown (drug effects)
  • Tooth Discoloration (chemically induced, prevention & control)

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