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[HBD-1 and hBD-2 are expressed in cervico-vaginal lavage in female genital tract due to microbial infections].

AbstractOBJECTIVES:
The aim of this study was to evaluate and compare concentration of selected human beta-defensins (hBD-1, hBD-2) in cervico-vaginal lavage (CVL), obtained from women with candidiasis, chlamydiasis and other bacterial infections.
MATERIAL AND METHODS:
beta-defensins were detected quantitatively by RT-PCR (7000 Taqman, Applied Biosystems) in cervico-vaginal lavage collected from 120 (79 women in the study group and 41 controls) non-pregnant women, aged 18-40 (mean age 28.5 +/- 6.29). The study group patients were divided into three subgroups on the basis of clinical and microbiological diagnosis: women with candidiasis (n=13); with chlamydiasis (n=13), and with other bacterial infections (n=12).
RESULTS:
The highest count of hBD-1 RNA copies was found in women with bacterial infections and candidiasis (335.84 and 320.10 respectively), and hBD-2--with chlamydiasis. The difference between RNA copies of hBD-1/microg in candidiasis, chlamydiasis and bacterial pathogens was statistically significant; for hBD-2 only in case of chlamydiasis.
CONCLUSIONS:
Chlamydia trachomatis infection activates the production of hBD-2. Candida albicans, Chlamydia trachomatis, and bacterial pathogens induced variable increases of hBD-1 concentration.
AuthorsBarbara Wiechuła, Krzysztof Cholewa, Alicja Ekiel, Małgorzata Romanik, Hanna Dolezych, Gayane Martirosian
JournalGinekologia polska (Ginekol Pol) Vol. 81 Issue 4 Pg. 268-71 (Apr 2010) ISSN: 0017-0011 [Print] Poland
Vernacular TitleEkspresja hBD-1 i hBD-2 w popłuczynach pochwowo-szyjkowych z dróg rodnych kobiet w stanach zapalnych wywołanych drobnoustrojami.
PMID20476598 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Biomarkers
  • DEFB1 protein, human
  • DEFB4A protein, human
  • beta-Defensins
Topics
  • Adult
  • Biomarkers (metabolism)
  • Candidiasis, Vulvovaginal (diagnosis, metabolism)
  • Cervix Mucus (microbiology)
  • Chlamydia Infections (diagnosis, metabolism)
  • Colony Count, Microbial
  • Female
  • Genital Diseases, Female (diagnosis, metabolism, microbiology)
  • Humans
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sexually Transmitted Diseases, Bacterial (diagnosis, metabolism)
  • Vagina (metabolism)
  • Vaginal Smears (methods)
  • Young Adult
  • beta-Defensins (metabolism)

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