Abstract | OBJECTIVE: METHODS: The diffuse traumatic brain injury of rats was induced by the Marmarou's 'weight-drop' device. And the immunohistochemical technique was used to detect the expression changes of neuroglobin and neuron apoptosis in rat brain at different time points post-injury. RESULTS: The expression of neuroglobin increased twice and reached peaks at 2 hours and 72 hours post-injury respectively. And the increased expression of neuroglobin from 30 minutes to 1 hour post-injury and from 48 hours to 72 hours post-injury accompanied with the decreased expression ratio of Bax to Bcl-2. CONCLUSION:
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Authors | Xin Lin, Min Li, Ya-zhuo Hu, Zhi-tao Han, Hong-hong Zhang, Ai-jia Shang, De-wei Gao, Ding-biao Zhou |
Journal | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
(Zhongguo Ying Yong Sheng Li Xue Za Zhi)
Vol. 26
Issue 1
Pg. 39-44
(Feb 2010)
ISSN: 1000-6834 [Print] China |
PMID | 20476562
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nerve Tissue Proteins
- Neuroglobin
- Globins
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Topics |
- Animals
- Apoptosis
(physiology)
- Brain
(metabolism, pathology)
- Brain Injuries
(metabolism, pathology)
- Globins
(metabolism)
- Male
- Nerve Tissue Proteins
(metabolism)
- Neuroglobin
- Neurons
(pathology)
- Random Allocation
- Rats
- Rats, Sprague-Dawley
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