Abstract | BACKGROUND & AIMS:
Butyrate, produced by colonic fermentation of dietary fibers is often hypothesized to beneficially affect colonic health. This study aims to assess the effects of butyrate on inflammation and oxidative stress in subjects with chronically mildly elevated parameters of inflammation and oxidative stress. METHODS: RESULTS: CONCLUSION: Although UC patients in remission were characterized by low-grade oxidative stress and inflammation, rectal butyrate enemas showed only minor effects on inflammatory and oxidative stress parameters.
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Authors | Henrike M Hamer, Daisy M A E Jonkers, Steven A L W Vanhoutvin, Freddy J Troost, Ger Rijkers, Adriaan de Bruïne, Aalt Bast, Koen Venema, Robert-Jan M Brummer |
Journal | Clinical nutrition (Edinburgh, Scotland)
(Clin Nutr)
Vol. 29
Issue 6
Pg. 738-44
(Dec 2010)
ISSN: 1532-1983 [Electronic] England |
PMID | 20471725
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. |
Chemical References |
- Antioxidants
- Butyrates
- Interleukin-10
- Interleukin-12
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Topics |
- Adult
- Aged
- Antioxidants
(metabolism)
- Biopsy
- Butyrates
(therapeutic use)
- Colitis, Ulcerative
(drug therapy, pathology)
- Colon
(metabolism, pathology)
- Double-Blind Method
- Enema
- Female
- Humans
- Inflammation
(drug therapy)
- Interleukin-10
(metabolism)
- Interleukin-12
(metabolism)
- Male
- Middle Aged
- Mucous Membrane
- Oxidative Stress
(drug effects)
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