Abstract | BACKGROUND: METHODS: Peripheral blood mononuclear cells from 304 Tanzanian children aged 6-72 months were stimulated with P. falciparum-parasitized erythrocytes obtained from in vitro cultures. RESULTS: The results showed a significant increase by 74% in geometric mean of TNF production in malaria-infected individuals with zinc deficiency (11% to 240%; 95% CI). Iron deficiency anaemia was associated with increased TNF production in infected individuals and overall with increased IL-10 production, while magnesium deficiency induced increased production of IL-10 by 46% (13% to 144%) in uninfected donors. All donors showed a response towards IL-1beta production, drawing special attention for its possible protective role in early innate immune responses to malaria. CONCLUSIONS: In view of these results, the findings show plasticity in cytokine profiles of mononuclear cells reacting to malaria infection under conditions of different micronutrient deficiencies. These findings lay the foundations for future inclusion of a combination of precisely selected set of micronutrients rather than single nutrients as part of malaria vaccine intervention programmes in endemic countries.
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Authors | Erasto V Mbugi, Marjolein Meijerink, Jacobien Veenemans, Prescilla V Jeurink, Matthew McCall, Raimos M Olomi, John F Shao, Hans Verhoef, Huub Fj Savelkoul |
Journal | Malaria journal
(Malar J)
Vol. 9
Pg. 130
(May 17 2010)
ISSN: 1475-2875 [Electronic] England |
PMID | 20470442
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Tumor Necrosis Factor-alpha
- Interleukin-10
- Zinc
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Topics |
- Anemia, Iron-Deficiency
(blood, complications, immunology)
- Case-Control Studies
- Child
- Child, Preschool
- Cross-Sectional Studies
- Cytokines
(biosynthesis, blood)
- Female
- Humans
- Infant
- Interleukin-10
(biosynthesis, blood)
- Magnesium Deficiency
(blood, complications, immunology)
- Malaria, Falciparum
(complications, immunology, parasitology)
- Male
- Plasmodium falciparum
(immunology)
- Tanzania
- Tumor Necrosis Factor-alpha
(biosynthesis, blood)
- Zinc
(blood, deficiency, immunology)
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