Abstract | BACKGROUND:
Vitamin C has been used for the treatment of hyperpigmented diseases. However, there is no study available on hypopigmenting effect of multivitamin. OBJECTIVES: To investigate the inhibitory effects of multivitamin and vitamin C on melanogenesis. METHODS: RESULTS: Both vitamin C and multivitamin inhibited melanogenesis with low cytotoxicity. Multivitamin reduced melanin contents greater than vitamin C. However, the effects of vitamin C are greater than those of multivitamin on mushroom tyrosinase inhibition and antioxidation. In the Western blot, the reduced tyrosinase expression and MITF level were observed only in multivitamin-treated group, and not in vitamin C-treated group. No changes of ERK and Akt activation were observed in both multivitamin and vitamin C-treated groups. After 12 weeks of treatment with iontophoresis, both multivitamin and vitamin C were effective for melasma. CONCLUSIONS: Multivitamin has shown more anti-melanogenic effect than vitamin C via the downregulation of MITF.
|
Authors | Yang Kyu Choi, Yong Kwan Rho, Kwang Ho Yoo, Yun Young Lim, Kapsok Li, Beom Joon Kim, Seong Jun Seo, Myeung Nam Kim, Chang Kwun Hong, Dong-Seok Kim |
Journal | International journal of dermatology
(Int J Dermatol)
Vol. 49
Issue 2
Pg. 218-26
(Feb 2010)
ISSN: 1365-4632 [Electronic] England |
PMID | 20465650
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Free Radicals
- Melanins
- Microphthalmia-Associated Transcription Factor
- Vitamins
- Monophenol Monooxygenase
- Ascorbic Acid
|
Topics |
- Animals
- Ascorbic Acid
(pharmacology, therapeutic use)
- Blotting, Western
- Cells, Cultured
- Colorimetry
- Double-Blind Method
- Free Radicals
(metabolism)
- Humans
- In Vitro Techniques
- Iontophoresis
(methods)
- Melanins
(metabolism)
- Melanocytes
(drug effects)
- Melanosis
(drug therapy, physiopathology)
- Mice
- Microphthalmia-Associated Transcription Factor
(metabolism)
- Monophenol Monooxygenase
(metabolism)
- Reference Values
- Statistics, Nonparametric
- Treatment Outcome
- Vitamins
(pharmacology, therapeutic use)
|