2.5% and 10% phenylephrine for mydriasis in diabetic patients with darkly pigmented irides.

Abstract

OBJECTIVE:

To compare the clinical efficacy and systemic side effects of2.5% and 10%phenylephrinefor mydriasis in diabetic patient with darkly pigmented irides.

MATERIAL AND METHOD:

A prospective randomized double-blind controlled trial was conducted. One hundred diabetic patients were randomly allocated into 2.5% and 10% phenylephrine groups by block randomization. Pupil diameter, blood pressure and heart rate were measured before and after eye drop instillations.

RESULTS:

The mean pupil diameters after instillation in the right eye were 7.05 +/- 0.71 mm (2.5% phenylephrine group) and 7.40 +/- 0.72 mm (10% phenylephrine group, p = 0.02) and in the left eye were 7.05 +/- 0.72 mm (2.5% phenylephrine group) and 7.39 +/- 0.72 mm (10% phenylephrine group, p = 0.02). There was no clinically significant difference in mean heart rate, mean systolic and diastolic blood pressure.

CONCLUSION:

In diabetic patients with darkly pigmented irides, 10% phenylephrine is more effective than 2.5% phenylephrine with statistical significance. The authors recommend a single dose of 10% phenyleprine for mydriasis in these patients. However the lower concentration is recommended for use in those who exhibit a higher prevalence ofsignificant vascular disease and autonomic dysfunction and seem to be susceptible to severe adverse reaction of phenylephrine.

• Authors: Olan Suwan-Apichon, Tanapat Ratanapakorn, Ronakorn Panjaphongse, Suthasinee Sinawat, Thuss Sanguansak, Yosanan Yospaiboon
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 93 Issue 4 Pg. 467-73 (Apr 2010) ISSN: 0125-2208 [Print] Thailand
• PMID: 20462091 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Mydriatics
• Ophthalmic Solutions
• Phenylephrine

Topics

• Adult
• Aged
• Cohort Studies
• Diabetic Retinopathy (complications, drug therapy, pathology)
• Double-Blind Method
• Eye Color
• Female
• Humans
• Male
• Middle Aged
• Mydriasis (drug therapy, etiology, pathology)
• Mydriatics (administration & dosage)
• Ophthalmic Solutions
• Phenylephrine (administration & dosage)
• Treatment Outcome
• Young Adult