Abstract | AIM AND METHODS: The treatment of mild-moderate acne with topical drugs in association with appropriate cosmetics is currently the golden standard. The tolerability and efficacy of a cream formulated with a new mix of alpha- hydroxy acids (Hyseac AHA cream) in 248 patients with mild-moderate acne (comedonic, inflammatory, or mixed) have been investigated in a multicenter, non-randomized, open study by 10 dermatologists from different Italian areas during their routine practice. The medication with Hyseac AHA cream was prescribed at first consultation for 60 days, twice a day, either as a monotherapy (49.2% patients) or in association with a pharmacological treatment (50.2%). RESULTS: The tolerability was good to excellent in 92.3% patients, without significant differences between patients using AHA cream in monotherapy (90.0%) or associated with concomitant pharmacological treatment (97.6%). The efficacy was overall high in 64.2% patients, again without significant differences related to concomitant pharmacological treatment or not (64.8% vs. 63.3%) and/or the acne clinical type (comedonic vs. inflammatory vs. mixed: 69.2% vs. 66.7% vs. 58%). CONCLUSION: The results of this study, while confirming the high tolerability and efficacy of this AHA cream in the treatment of mild/moderate acne, reasonably suggest its possible use also in monotherapy. Furthermore, its use can be reasonably hypothesized as a maintenance treatment after specific pharmacological treatment even in more severe acne types.
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Authors | A Baldo, P Bezzola, S Curatolo, T Florio, G Lo Guzzo, M Lo Presti, G P Sala, F Serra, E Tonin, M Pellicano, N Pimpinelli |
Journal | Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia
(G Ital Dermatol Venereol)
Vol. 145
Issue 3
Pg. 319-22
(Jun 2010)
ISSN: 0392-0488 [Print] Italy |
PMID | 20461041
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Acne Vulgaris
(drug therapy)
- Adolescent
- Adult
- Child
- Female
- Humans
- Hydroxy Acids
(therapeutic use)
- Male
- Middle Aged
- Severity of Illness Index
- Young Adult
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