Garlic oil as a modulating agent for oxidative stress and neurotoxicity induced by sodium nitrite in male albino rats.

Abstract

In the present study, we investigated the neurobiochemical alterations and oxidative stress induced by food preservative; sodium nitrite (NaNO2) as well as the role of the garlic oil in amelioration of the neurotoxicity in male albino rats. Serum and brain homogenates of the rats received NaNO2 (80 mg/kg body weight) for 3 months exhibited significant decrease in acetylcholine esterase (AChE) activity as well as the levels of phospholipids, total protein and the endogenous antioxidant system (glutathione; GSH and superoxide dismutase; SOD). In contrast, lactic dehydrogenase (LDH) activity, brain thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO) levels were significantly increased. On the other hand, the oral administration of garlic oil (5 ml/kg body weight) daily for 3 months significantly improved the neurobiochemical disorders and inhibited the oxidative stress induced by NaNO2 ingestion. So, this study reveals the neural toxic effects of NaNO2 by exerting oxidative stress and retrograde the endogenous antioxidant system. However, garlic oil has a promising role in attenuating the obtained hazard effects of sodium nitrite by its high antioxidant properties which may eventually be related with the preservation of SOD activity and primary mitochondrial role against nitrite-induced neurotoxicity in rats.

• Authors: Hanaa A Hassan, Hani S Hafez, Fawzia E Zeghebar
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 48 Issue 7 Pg. 1980-5 (Jul 2010) ISSN: 1873-6351 [Electronic] England
• PMID: 20457208 (Publication Type: Journal Article)
• Copyright: 2010 Elsevier Ltd. All rights reserved.

Chemical References

• Allyl Compounds
• Free Radicals
• Phospholipids
• Sulfides
• Thiobarbituric Acid Reactive Substances
• Nitric Oxide
• allyl sulfide
• L-Lactate Dehydrogenase
• Superoxide Dismutase
• Acetylcholinesterase
• Sodium Nitrite

Topics

• Acetylcholinesterase (blood)
• Allyl Compounds (pharmacology)
• Animals
• Brain Chemistry (drug effects)
• Free Radicals (metabolism)
• L-Lactate Dehydrogenase (blood)
• Lipid Peroxidation (drug effects)
• Male
• Neurotoxicity Syndromes (prevention & control)
• Nitric Oxide (metabolism)
• Oxidative Stress (drug effects)
• Phospholipids (blood)
• Rats
• Rats, Sprague-Dawley
• Sodium Nitrite (antagonists & inhibitors, toxicity)
• Sulfides (pharmacology)
• Superoxide Dismutase (metabolism)
• Thiobarbituric Acid Reactive Substances (metabolism)