Abstract | INTRODUCTION: We have reported that pica, kaolin ingestion behavior, correlates with nausea and vomiting in rats and the amount of kaolin intake is related to the severity of symptoms. However, the time course of the behavior is still unclear, because kaolin intake has been measured 24h after administration of an emetic stimulus. It is quite difficult and troublesome to determine kaolin intake manually at short time intervals without affecting the animal's behavior. In the present study, we investigated the time course of radiation or chemotherapeutic agent-induced pica in rats using an automatic feeding monitoring system (FDM700SW). METHODS: Rats received total body X-ray irradiation (4 Gy), or i.p. administration of cisplatin (6 mg/kg) or cyclophosphamide (120 mg/kg) with or without pretreatment of 5-HT(3) receptor antagonist, granisetron (0.1mg/kg, i.p.), then their kaolin and food intake were monitored hourly for 24h after the emetic stimuli. RESULTS: DISCUSSION: These results suggested that both the latency and the duration of pica are similar to the clinical evidence of radiation or chemotherapy-induced nausea and vomiting in human patients and this monitoring system is useful to evaluate the emetogenic potential of drugs and other medical intervention in preclinical studies.
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Authors | Kouichi Yamamoto, Keiko Asano, Naoki Matsukawa, Masahiro Imaizumi, Atsushi Yamatodani |
Journal | Journal of pharmacological and toxicological methods
(J Pharmacol Toxicol Methods)
2011 Jan-Feb
Vol. 63
Issue 1
Pg. 30-4
ISSN: 1873-488X [Electronic] United States |
PMID | 20451632
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2010 Elsevier Inc. All rights reserved. |
Chemical References |
- Antineoplastic Agents
- Serotonin Antagonists
- Kaolin
- Granisetron
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Topics |
- Animals
- Antineoplastic Agents
(administration & dosage, toxicity)
- Eating
- Feeding Behavior
- Feeding Methods
(instrumentation)
- Granisetron
(administration & dosage, therapeutic use)
- Kaolin
(administration & dosage, pharmacology)
- Male
- Nausea
(chemically induced, etiology)
- Pica
(chemically induced)
- Rats
- Rats, Wistar
- Serotonin Antagonists
(administration & dosage, therapeutic use)
- Time Factors
- Vomiting
(chemically induced, etiology)
- X-Rays
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