Enantioselective assembly of the benzo[d]xanthene tetracyclic core of anti-influenza active natural products.

Abstract

A combination of an enantioselective conjugate addition/trapping sequence and a ruthenium(iii)-catalyzed domino cyclization provides a concise access to benzo[d]xanthenes found in several anti-influenza active sesquiterpene natural products.

• Authors: Ngoc Duc Tran, Martin Albicker, Lorenz Schneider, Nicolai Cramer
• Journal: Organic & biomolecular chemistry (Org Biomol Chem) Vol. 8 Issue 8 Pg. 1781-4 (Apr 21 2010) ISSN: 1477-0539 [Electronic] England
• PMID: 20449479 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Xanthenes

Topics

• Antiviral Agents (chemical synthesis, chemistry)
• Catalysis
• Cyclization
• Humans
• Influenza, Human (drug therapy)
• Molecular Structure
• Xanthenes (chemical synthesis, chemistry)