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Disposition kinetics of sparfloxacin in healthy, hepatopathic, and nephropathic conditions in chicken after single intravenous administration.

AbstractOBJECTIVE:
To study the variation of disposition kinetic values of sparfloxacin in healthy, hepatopathic, and nephropathic chickens after a single intravenous administration.
MATERIALS AND METHODS:
Hepatotoxicity was induced by the administration of paracetamol (500 mg / kg / day, p.o. for seven days) and nephrotoxicity by uranyl nitrate (2.0 mg / kg / day dissolved in distilled water, i.v. for four days) in chickens. Disposition kinetic studies of sparfloxacin were investigated in healthy as well as hepatopathic and nephropathic birds after a single intravenous administration at 40 mg / kg body weight.
RESULTS:
Maximum plasma concentration detected at 0.16 hour was 31.25 +/- 2.95, 61.95 +/-1.85, and 99.86 +/- 2.21 mug / ml in healthy, hepatopathic, and nephropathic group, respectively. The drug could not be detected in the plasma of healthy birds beyond 12-hour period, while the same was detectable for 72 hour in the plasma of hepatopathic and nephropathic birds. The concentration of sparfloxacin was significantly (P < 0.01) higher in all the samples of hepathopathic and nephropathic birds compared to healthy birds. All the kinetic values were increased (P < 0.01) in the hepatopathic and nephropathic birds, except Vd(area) and Cl(B) values in hepatopathic Birds; while beta and Cl(B) values nephropathic birds were decreased significantly than that of healthy birds.
CONCLUSIONS:
The dose of sparfloxacin may be reduced in hepatopathic as well as nephropathic birds.
AuthorsM K Bhar, S Khargharia, A K Chakraborty, T K Mandal
JournalIndian journal of pharmacology (Indian J Pharmacol) Vol. 41 Issue 3 Pg. 106-9 (Jun 2009) ISSN: 1998-3751 [Electronic] India
PMID20442816 (Publication Type: Journal Article)

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