Expression of sarcolectin in the human pituitary gland and amniotic fluid.

Abstract

Sarcolectin (SCL) is a 55 kDa protein cross-reacting with a cytokeratin 7 monomer found in placental blood, sarcomas and various tissues. It blocks the synthesis of interferon-dependent secondary proteins, induces cell DNA activation and sensitizes cells to viral infection. SCL is a potent promoter of tissue growth. In the present report, we demonstrate that SCL is expressed in the human pituitary gland at the mRNA and protein levels. We show also its presence in human amniotic fluid in high titres while interferon titres is weak. These results allow to postulate a potential role of SCL as a growth factor participating in human foetal development.

• Authors: Jean-Pierre M'bika, Wael Khazen, Ammar Achour, Charles Chany
• Journal: Biochimie (Biochimie) Vol. 92 Issue 8 Pg. 1085-8 (Aug 2010) ISSN: 1638-6183 [Electronic] France
• PMID: 20438796 (Publication Type: Journal Article)
• Copyright: Copyright 2010 Elsevier Masson SAS. All rights reserved.

Chemical References

• DNA Primers
• Lectins
• sarcolectin

Topics

• Aged
• Aged, 80 and over
• Amniotic Fluid (metabolism)
• Base Sequence
• Blotting, Western
• DNA Primers
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunohistochemistry
• Lectins (metabolism)
• Male
• Middle Aged
• Pituitary Gland (metabolism)
• Polymerase Chain Reaction