[Acute bilateral angle-closure glaucoma induced by topiramate: contribution of Visante OCT].

Abstract

INTRODUCTION:

Topiramate, a sulfamate-substituted monosaccharide classically used as an antiepileptic medication, has been widely used since its recent indication for migraine prophylaxis. We report the case of a 68-year-old woman who developed bilateral acute glaucoma following topiramate migraine prophylaxis.

OBSERVATION:

A 68-year-old woman presented in the emergency department for ocular pain, redness, and bilateral reduced visual acuity associated with nausea and vomiting. Initial examination found a bilateral corneal edema with shallow anterior chambers and closed iridocorneal angles. Intraocular pressure was 40mmHg in the right eye and 45mmHg in the left eye. Ultrasound biomicroscopy diagnosed ciliochoroidal detachment and swollen ciliary processes with closed angles, which was also objectified using the Visante OCT. Topiramate treatment was interrupted and a local and general hypotonic treatment was started. After 4 days, examination showed deeper anterior chambers and normal intraocular pressures. Visante OCT and ocular echography follow-up examinations were normal, and Indoramin was prescribed for migraine prophylaxis with no relapse after 10 months.

CONCLUSION:

Bilateral acute angle-closure glaucoma is a possible complication of topiramate. Physicians and patients starting this therapy should be aware of this underestimated risk.

• Authors: R Tahiri Joutei Hassani, S Dupont Monod, G Oukacha, F Mantout, R Benrabah, E Heron, C Baudouin
• Journal: Journal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 33 Issue 5 Pg. 307-11 (May 2010) ISSN: 1773-0597 [Electronic] France
• Vernacular Title: Crise bilatérale de glaucome aigu après traitement par topiramate : apport de l'OCT Visante.
• PMID: 20434235 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2010 Elsevier Masson SAS. All rights reserved.

Chemical References

• Anticonvulsants
• Topiramate
• Fructose

Topics

• Acute Disease
• Aged
• Anticonvulsants (adverse effects)
• Female
• Fructose (adverse effects, analogs & derivatives)
• Glaucoma, Angle-Closure (chemically induced, diagnosis)
• Humans
• Tomography, Optical Coherence
• Topiramate