Abstract | AIM: METHODS: We measured at baseline and one year later anthropometrics, percentage body fat based on skinfold thickness, DPP-IV, PP, PYY, insulin, and glucose concentrations in 18 obese children (mean age 10.9 years, 44% male, mean BMI 28.5 kg/m2) who participated in a one-year lifestyle intervention program based on physical activity, nutrition course, and behavioral therapy. Insulin sensitivity was calculated using QUICKI. RESULTS: Changes of DPP-IV correlated significantly to the changes of percentage body fat (r = 0.47) and BMI SDS (r = 0.60). In partial regression analysis adjusted for change in weight status, changes of DPP-IV correlated significantly to changes of PYY (r = -0.43), PP (r = -0.49), QUICKI (r = -0.53), and insulin (r = 0.57). The 10 children with substantial weight loss significantly reduced their DPP-IV and insulin concentrations, while QUICKI, PYY, and PP levels significantly increased. In children without substantial weight loss no significant changes were observed. CONCLUSIONS: These findings suggest that the increase of fasting PP and PYY in weight loss is influenced at least in part by a decrease of their cleavage enzyme DPP-IV. Further research is necessary to evaluate the mechanisms in weight loss leading to a decrease of DPP-IV activity and consequently to an improvement of insulin sensitivity.
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Authors | Thomas Reinehr, Christian L Roth, Pablo J Enriori, Kai Masur |
Journal | Journal of pediatric endocrinology & metabolism : JPEM
(J Pediatr Endocrinol Metab)
2010 Jan-Feb
Vol. 23
Issue 1-2
Pg. 101-8
ISSN: 0334-018X [Print] Germany |
PMID | 20432813
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Insulin
- Peptide YY
- Pancreatic Polypeptide
- DPP4 protein, human
- Dipeptidyl Peptidase 4
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Topics |
- Adolescent
- Ambulatory Care
- Blood Glucose
(metabolism)
- Child
- Child Health Services
- Dipeptidyl Peptidase 4
(blood)
- Female
- Humans
- Insulin
(blood)
- Insulin Resistance
- Life Style
- Male
- Obesity
(blood, therapy)
- Pancreatic Polypeptide
(blood)
- Peptide YY
(blood)
- Treatment Outcome
- Weight Loss
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