Abstract | BACKGROUND:
Plant sterols and stanols are plant steroids with a similar chemical structure and cellular function to human cholesterol, and are recommended as dietary modifiers of serum lipids. Plant sterols have a higher degree of absorption than plant stanols, suggesting differential efficacy between the two. DESIGN: A meta-analysis of randomized controlled trials was performed to summarize direct comparisons between the effect of plant sterols vs plant stanols on serum lipid levels in healthy patients and patients with hypercholesterolemia. METHODS: A systematic literature search of MEDLINE, EMBASE, Cochrane CENTRAL, and the Natural Medicines Comprehensive Database was conducted from January 1950 through January 2009. Trials were included in the analysis if they were randomized controlled trials evaluating the effect of plant sterols vs plant stanols in healthy patients or patients with hypercholesterolemia who reported efficacy data on total, low-density lipoprotein, and high-density lipoprotein cholesterols or triglycerides. The weighted mean difference (WMD) of the change from baseline (in mg/dL) with 95% confidence interval was calculated as the difference between the means in the plant sterol and plant stanol groups using a random-effects model. RESULTS: Fourteen studies (n=531 patients) met the inclusion criteria. Upon meta-analysis, the results showed that there is no statistically or clinically significant difference between plant sterols and plant stanols in their abilities to modify total cholesterol (WMD -1.11 mg/dL [-0.0286 mmol/L], 95% confidence interval [CI] -4.12 to 1.90, P=0.47), low-density lipoprotein cholesterol (WMD -0.35 mg/dL [-0.0091 mmol/L], 95% CI -2.98 to 2.28, P=0.79), high-density lipoprotein cholesterol (WMD -0.28 mg/dL [-0.00073 mmol/L], 95% CI -1.18 to 0.62, P=0.54), or triglycerides (WMD -1.80 mg/dL [-0.0203 mmol/L], 95% CI -6.80 to 3.21, P=0.48). CONCLUSIONS:
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Authors | Ripple Talati, Diana M Sobieraj, Sagar S Makanji, Olivia J Phung, Craig I Coleman |
Journal | Journal of the American Dietetic Association
(J Am Diet Assoc)
Vol. 110
Issue 5
Pg. 719-26
(May 2010)
ISSN: 1878-3570 [Electronic] United States |
PMID | 20430133
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Review, Systematic Review)
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Copyright | Copyright 2010 American Dietetic Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Anticholesteremic Agents
- Cholesterol, HDL
- Cholesterol, LDL
- Phytosterols
- Sitosterols
- Triglycerides
- plant stanol ester
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Topics |
- Anticholesteremic Agents
(therapeutic use)
- Cholesterol, HDL
(blood, drug effects)
- Cholesterol, LDL
(blood, drug effects)
- Humans
- Hyperlipidemias
(blood, drug therapy)
- Lipid Metabolism
(drug effects)
- Phytosterols
(therapeutic use)
- Phytotherapy
- Randomized Controlled Trials as Topic
- Sitosterols
(therapeutic use)
- Treatment Outcome
- Triglycerides
(blood)
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