Anterior vaginal wall prolapse: a randomized controlled trial of SIS graft versus traditional colporrhaphy.

Abstract

INTRODUCTION AND HYPOTHESIS:

This study seeks to compare the small intestine submucosa (SIS) graft with traditional colporrhaphy (TC) for surgical treatment of anterior vaginal prolapse.

METHODS:

Subjects were randomly assigned to SIS (n = 29) or to TC (n = 27) preoperatively and outcomes analyzed at 12 months postoperatively. The primary outcome was the absence of POP-Q stage >or= II prolapse, and secondary outcome was improvement in quality of life. Data were compared with independent samples or paired Student's t test.

RESULTS:

SIS group had 86.2% anatomic cure compared to 59.3% in TC (p = 0.03). SIS improved point Ba measurement significantly (-1.93 cm versus -1.37 cm, p = 0.02). Both operations significantly improved quality of life, although there were no differences between the groups. We observed a greater number of complications in the SIS group, with no infections or erosion.

CONCLUSIONS:

SIS repair improved point Ba significantly. However, there were no differences observed in quality of life between the techniques.

• Authors: Paulo Cezar Feldner Jr, Rodrigo Aquino Castro, Luiz Antonio Cipolotti, Carlos Antonio Delroy, Marair Gracio Ferreira Sartori, Manoel João Batista Castello Girão
• Journal: International urogynecology journal (Int Urogynecol J) Vol. 21 Issue 9 Pg. 1057-63 (Sep 2010) ISSN: 1433-3023 [Electronic] England
• PMID: 20428997 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Topics

• Colpotomy (methods)
• Female
• Follow-Up Studies
• Humans
• Intestinal Mucosa (transplantation)
• Middle Aged
• Quality of Life
• Surveys and Questionnaires
• Time Factors
• Treatment Outcome
• Uterine Prolapse (surgery)