Midkine regulation of the renin-angiotensin system.

Abstract

Hypertension and chronic kidney disease are often associated. The pathogenesis of these diseases involves the renin-angiotensin system. We have recently reported that the growth factor midkine is a novel regulator of the renin-angiotensin system. Midkine is a heparin-binding growth factor so far implicated in neuronal differentiation, neuroprotection, cardioprotection, inflammation, and cancer development. In a mouse model of chronic kidney disease induced by 5/6 nephrectomy, midkine is produced in the lung and in turn upregulates angiotensin-converting enzyme expression. Hypertension associated with 5/6 nephrectomy is not observed in midkine-deficient mice. Conversely, supplemental administration of midkine to the deficient mice induces hypertension. This review describes the molecular characteristics of midkine and its significance in the renin-angiotensin system and the kidney-lung interaction.

• Authors: Kenji Kadomatsu
• Journal: Current hypertension reports (Curr Hypertens Rep) Vol. 12 Issue 2 Pg. 74-9 (Apr 2010) ISSN: 1534-3111 [Electronic] United States
• PMID: 20424942 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Cytokines
• Receptors, Fibroblast Growth Factor
• Angiotensin II
• Midkine
• Aldosterone
• Fibroblast Growth Factors
• Acetylcholinesterase
• Renin

Topics

• Acetylcholinesterase (biosynthesis)
• Acute Kidney Injury
• Aldosterone
• Angiotensin II
• Animals
• Central Nervous System
• Cytokines (physiology)
• Fibroblast Growth Factors
• Humans
• Hypertension (pathology)
• Inflammation (pathology)
• Kidney Failure, Chronic (pathology)
• Lung
• Mice
• Midkine
• Receptors, Fibroblast Growth Factor
• Renin
• Renin-Angiotensin System (physiology)
• Risk Factors