Abstract | BACKGROUND: OBJECTIVE: We evaluated serum concentrations of certain noncoplanar PCBs, which have no or only weak dioxin-like properties, as risk factors for endometriosis. METHODS: In a case-control study of Group Health enrollees in western Washington State, 20 PCB congeners were measured in serum from surgically confirmed endometriosis cases that were newly diagnosed between 1996 and 2001 (n = 251) and from female controls matched for age and reference year (n = 538). RESULTS: Summed and estrogenic PCB concentrations were not associated with endometriosis risk [summed: odds ratio (OR) = 1.3; 95% confidence interval (CI), 0.8-2.2; estrogenic: OR = 1.1; 95% CI, 0.8-1.4]. Although several congener-specific ORs were statistically above or below the null ( PCB 170: third quartile vs. lowest: OR = 0.5; 95% CI, 0.3-0.9; PCB 196: third quartile vs. lowest: OR = 0.4; 95% CI, 0.2-0.7; PCB 201: second vs. lowest: OR = 0.5; 95% CI, 0.3-0.8; third quartile vs. lowest: OR = 0.4; 95% CI, 0.2-0.7), there were no overall consistent patterns of endometriosis risk. CONCLUSIONS: Taken in context with other North American studies, our findings suggest that noncoplanar PCB concentrations consistent within the range of exposure currently observed in western Washington State do not contribute meaningfully to endometriosis risk.
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Authors | Britton Trabert, Anneclaire J De Roos, Stephen M Schwartz, Ulrike Peters, Delia Scholes, Dana B Barr, Victoria L Holt |
Journal | Environmental health perspectives
(Environ Health Perspect)
Vol. 118
Issue 9
Pg. 1280-5
(Sep 2010)
ISSN: 1552-9924 [Electronic] United States |
PMID | 20423815
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Polychlorinated Biphenyls
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Topics |
- Adolescent
- Adult
- Endometriosis
(blood, etiology)
- Female
- Humans
- Middle Aged
- Polychlorinated Biphenyls
(blood, toxicity)
- Young Adult
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