Screening for glucose-6-phosphate dehydrogenase deficiency in blood donors.

Abstract

AIM:

Our purpose was to determine the frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency in blood donors of Jahrom, Iran.

METHODS:

Blood samples were obtained from the 706 blood donors who referred to Jahrom Blood Transfusion Organization between June and September 2008. Enzyme assays were performed three times, on day 1 (day of blood sampling), 7 and 45 days after blood storage. G6PD activity was measured using a quantitative assay.

RESULTS:

A total of 706 samples were examined. 97.7% males and 2.3% females, mean age 32.6 years (18-64 years). Based on enzyme activity less than 1.62 IU/g hemoglobin (Hb), prevalence of G6PD deficiency in three separate measurements was 16.3, 19.1 and 33.3% respectively. Four percent of donor had an enzyme level of zero on day 1 which increased to 7.4 and 10.7% on the seventh and the forty-fifth days.

CONCLUSION:

The results of this study support the screening for G6PD as part of the routine workup of blood donors in areas with a high prevalence of G6PD deficiency.

• Authors: Fatemeh Emamghorashi, Farhang Hoshmand, Abdolrahman Mohtashamifar
• Journal: Hematology (Amsterdam, Netherlands) (Hematology) Vol. 15 Issue 2 Pg. 122-4 (Apr 2010) ISSN: 1607-8454 [Electronic] England
• PMID: 20423573 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glucose-6-Phosphatase

Topics

• Adolescent
• Adult
• Blood Donors
• Ethnicity (statistics & numerical data)
• Female
• Glucose-6-Phosphatase (blood)
• Glycogen Storage Disease Type I (blood, diagnosis, epidemiology, ethnology)
• Humans
• Iran (epidemiology)
• Male
• Mass Screening
• Middle Aged
• Young Adult