A practical approach to the prevention of miscarriage: part 2--active immunotherapy.

Abstract

PURPOSE:

To present data suggesting that active immunization with lymphocyte immunotherapy is a treatment that has benefit in preventing miscarriage.

METHODS:

Lymphocyte immunotherapy is given to women with a history of recurrent miscarriage or failure to achieve a successful pregnancy, despite several previous embryo transfers. Active immunization was combined with progesterone therapy. The lymphocytes were not refrigerated, but used fresh.

RESULTS:

Compared to controls, i.e., progesterone therapy alone, the injection of paternal lymphocytes intradermally improved miscarriage rates and improved live delivered pregnancy rates per embryo transfer.

CONCLUSIONS:

The addition of progesterone treatment may act synergistically with lymphocyte immunotherapy, especially in primary aborters and tertiary aborters. However, it is important to use fresh--not refrigerated--stored lymphoctes.

• Authors: J H Check
• Journal: Clinical and experimental obstetrics & gynecology (Clin Exp Obstet Gynecol) Vol. 37 Issue 1 Pg. 5-9 ( 2010) ISSN: 0390-6663 [Print] Singapore
• PMID: 20420268 (Publication Type: Editorial)

Chemical References

• PIBF1 protein, human
• Pregnancy Proteins
• Progestins
• Suppressor Factors, Immunologic
• Progesterone

Topics

• Abortion, Habitual (prevention & control)
• Combined Modality Therapy
• Embryo Transfer
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunotherapy, Active
• Injections, Intradermal
• Live Birth
• Lymphocyte Transfusion
• Male
• Pregnancy
• Pregnancy Proteins (blood)
• Pregnancy Rate
• Progesterone (therapeutic use)
• Progestins (therapeutic use)
• Specimen Handling
• Suppressor Factors, Immunologic (blood)