Choroidal neovascular membrane in persistent fetal vasculature syndrome managed with intravitreal pegaptanib sodium in an infant.

Abstract

PURPOSE:

The purpose of this study was to report the successful management of a case of choroidal neovascular membrane secondary to persistent fetal vasculature syndrome in an infant using intravitreal pegaptanib sodium (Macugen).

METHODS:

A 14-month-old male infant developed a peripapillary choroidal neovascular membrane 10 months after lens-sparing vitrectomy that he underwent for persistent fetal vasculature syndrome and confirmed on angiography and optical coherence tomography. A single dose of intravitreal pegaptanib sodium (0.3 mg) was administered after informed consent was obtained. Angiography and optical coherence tomography scans were performed at 6 and 14 weeks after the injection to determine the result.

RESULTS:

Six weeks after the single injection, the lesion reduced in size and exhibited less leakage on angiography. At 14 weeks, leakage was absent, and the lesion had involuted.

CONCLUSION:

Choroidal neovascular membrane in a case of persistent fetal vasculature syndrome is rare. This report shows that intravitreal pegaptanib sodium is highly effective in treating this lesion even in an infant.

• Authors: Anand Vinekar, Newman Sund, Polly Quiram, Antonio Capone Jr
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 30 Issue 4 Suppl Pg. S41-4 (Apr 2010) ISSN: 1539-2864 [Electronic] United States
• PMID: 20419850 (Publication Type: Case Reports, Journal Article)

Chemical References

• Aptamers, Nucleotide
• Vascular Endothelial Growth Factor A
• pegaptanib

Topics

• Aptamers, Nucleotide (therapeutic use)
• Choroidal Neovascularization (diagnosis, drug therapy, etiology, physiopathology)
• Fluorescein Angiography
• Humans
• Infant
• Injections
• Male
• Persistent Hyperplastic Primary Vitreous (surgery)
• Postoperative Complications
• Tomography, Optical Coherence
• Vascular Endothelial Growth Factor A (antagonists & inhibitors)
• Visual Acuity (physiology)
• Vitrectomy
• Vitreous Body