A case of severe MAGIC syndrome treated successfully with the tumor necrosis factor-alpha inhibitor infliximab.

Abstract

We report a patient with an overlap of relapsing polychondritis and Behcet disease whose cartilaginous inflammation and genital lesions were refractory to corticosteroids and immunosuppressants, but fully remitted with the tumor necrosis factor-alpha inhibitor, infliximab. We believe this case represents the first report of a response to a tumor necrosis factor inhibitor in a patient with mouth and genital ulcerations with inflamed cartilage syndrome.

• Authors: Erik D Geissal, Richard Wernick
• Journal: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases (J Clin Rheumatol) Vol. 16 Issue 4 Pg. 185-7 (Jun 2010) ISSN: 1536-7355 [Electronic] United States
• PMID: 20414125 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Antibodies, Monoclonal
• Tumor Necrosis Factor-alpha
• Infliximab

Topics

• Adult
• Anti-Inflammatory Agents (therapeutic use)
• Antibodies, Monoclonal (therapeutic use)
• Behcet Syndrome (complications, drug therapy)
• Humans
• Infliximab
• Male
• Polychondritis, Relapsing (complications, drug therapy)
• Remission Induction
• Syndrome
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)