Inflammatory reaction is always accompanied by increased intensity of
free-radical oxidation, especially when the phenomena of
hypoxia and microcirculatory disorders that occur during the development of side-effects of acrylic removable
dentures. This study determined the effectiveness of adaptogens,
antioxidants in the complex treatment of diseases of tissues prosthetic field and their influence on the processes of LPO in whole mixed unstimulated saliva. Formed in the reaction to initiate the process of
oxygen radicals (
OH, RO, O(2)), initiate the formation of
lipid peroxide radicals RO(2)
biological substrate, the recombination of which leads to the emergence of unsustainable tetroxids, which decays with the release of light quanta. This luminescence is recorded as an amplified current of the photomultiplier, the registration systems. The results suggest the intensive formation of
free radicals and
peroxides in diseased tissue prosthetic field. Probably the main reason for increasing
free-radical oxidation is the release of
peroxidase from the crumbling
inflammation, phagocytes (mainly neutrophils). The process of peroxidation contributes to an increase in blood supply to inflamed tissues, leading to local enrichment of
oxygen, as well as toxic effects of acrylic bases of partial and complete removable
dentures in the prosthetic field of tissue. Effect of
antioxidants in combination with traditional treatment in 70 patients with
periodontal disease and prosthetic bed was assessed by chemiluminescence analysis of whole mixed unstimulated saliva. The level of lipid peroxidation and chemiluminescence activity exceeded the normal values in the 1,5-2 - twice before the treatment.
After treatment with
antioxidants, these parameters decreased and increased during remission. Thus, studies to determine the status of saliva chemiluminescence method to treat and monitor the dynamics
after treatment of
periodontitis tissues supporting teeth prosthetic field in the control group and the main observation, revealed the following pattern: the approach of all the indices to normal in patients with a core group, which corresponded to the clinical dynamic index parameters of periodontal tissues supporting teeth prosthetic field, and a similar core group of the positive dynamics of the intensity values of chemiluminescence-indicators in the control group up to 3 months of observation, with a significant deterioration of the same indicators at a later time dynamic monitoring.