Abstract | AIM: METHODS: We prospectively evaluated 10 consecutive NASH patients with dyslipidemia who agreed to participate in this study. The patients were given ezetimibe (10 mg/day) for 6 months, and clinical parameters and histological alterations were comparatively evaluated before and after treatment. All the patients were given standard calorie diet (30 kcal/kg per day, carbohydrate 50-60%, fat 20-30%, protein 15-20%) and exercise counseling from 3 months before the ezetimibe treatment. RESULTS: CONCLUSION: Major clinical parameters and histological observations were significantly improved by the treatment with ezetimibe. Our pilot study demonstrated the efficacy of ezetimibe for drug therapy of NASH and may lead to a large-scale clinical trial in the future.
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Authors | Masato Yoneda, Koji Fujita, Yuichi Nozaki, Hiroki Endo, Hirokazu Takahashi, Kunihiro Hosono, Kaori Suzuki, Hironori Mawatari, Hiroyuki Kirikoshi, Masahiko Inamori, Satoru Saito, Tomoyuki Iwasaki, Yasuo Terauchi, Kensuke Kubota, Shiro Maeyama, Atsushi Nakajima |
Journal | Hepatology research : the official journal of the Japan Society of Hepatology
(Hepatol Res)
Vol. 40
Issue 6
Pg. 566-73
(Jun 2010)
ISSN: 1872-034X [Electronic] Netherlands |
PMID | 20412324
(Publication Type: Journal Article)
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