Abstract |
Limited information is available on the use of botulinum toxin type A injections for children with hereditary spastic paraplegia. This report includes 12 children with hereditary spastic paraplegia (mean age 4.8 +/- 2.5 years) who underwent 1 to 6 sessions of botulinum toxin A injections to the hamstrings, adductors and gastrocnemius muscles. Patients showed both improved muscle tone (mean 1.9 +/- 0.5 vs 1.18 +/- 0.33, P < .001, Ashworth Scale) and motor function (75.3 +/- 11.9 vs 77.7 +/- 11, P < .001, Gross Motor Function Measure). The effect lasted for a mean of 6.6 +/- 3.6 months. During the study period (mean 2.8 +/- 1.8 years), the preinjection Gross Motor Function Measure increased (69.2 +/- 14.7 vs 78.3 +/- 13.5, P = .005), whereas the Ashworth Scale remained stable, suggesting a prolonged effect of botulinum toxin A on motor function. The authors conclude that botulinum toxin A injections to lower limbs of pediatric patients with hereditary spastic paraplegia result in prolonged functional improvement despite the progressive nature of the disease.
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Authors | Keren Geva-Dayan, Dafna Domenievitz, Rafat Zahalka, Aviva Fattal-Valevski |
Journal | Journal of child neurology
(J Child Neurol)
Vol. 25
Issue 8
Pg. 969-75
(Aug 2010)
ISSN: 1708-8283 [Electronic] United States |
PMID | 20406997
(Publication Type: Journal Article)
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Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
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Topics |
- Activities of Daily Living
- Botulinum Toxins, Type A
(administration & dosage, adverse effects)
- Child
- Child, Preschool
- Female
- Humans
- Infant
- Male
- Muscle, Skeletal
(drug effects, physiopathology)
- Neuromuscular Agents
(administration & dosage, adverse effects)
- Outcome Assessment, Health Care
(methods)
- Quality of Life
- Retrospective Studies
- Spastic Paraplegia, Hereditary
(drug therapy, physiopathology, psychology)
- Treatment Outcome
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