Increased risk for lymphoid and myeloid neoplasms in elderly solid-organ transplant recipients.
Abstract | BACKGROUND: METHODS: Using data from the U.S. Surveillance, Epidemiology, and End Results Medicare database, we identified 83,016 cases with a hematologic malignancy (age 66-99 years) and 166,057 population-based controls matched to cases by age, sex, and calendar year. Medicare claims were used to identify a history of solid- organ transplantation. We used polytomous logistic regression to calculate odds ratios (OR) comparing transplantation history among cases with various hematologic malignancy subtypes and controls, adjusting for the matching factors and race. RESULTS: A prior solid-organ transplant was identified in 216 (0.26%) cases and 204 (0.12%) controls. Transplantation was associated with increased risk for non-Hodgkin lymphomas [OR, 2.13; 95% confidence interval (95% CI), 1.67-2.72], especially diffuse large B-cell lymphoma (OR, 3.29; 95% CI, 2.28-4.76), marginal zone lymphoma (OR, 2.48; 95% CI, 1.17-5.22), lymphoplasmacytic lymphoma (OR, 3.32; 95% CI, 1.41-7.81), and T-cell lymphoma (OR, 3.07; 95% CI, 1.56-6.06). Transplantation was also associated with elevated risk of Hodgkin lymphoma (OR, 2.53; 95% CI, 1.01-6.35) and plasma cell neoplasms (OR, 1.91; 95% CI, 1.24-2.93). Risks for myeloid neoplasms were also elevated (OR, 1.99; 95% CI, 1.41-2.81). CONCLUSION: IMPACT:
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Authors | Scott C Quinlan, Lindsay M Morton, Ruth M Pfeiffer, Lesley A Anderson, Ola Landgren, Joan L Warren, Eric A Engels |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 19
Issue 5
Pg. 1229-37
(May 2010)
ISSN: 1538-7755 [Electronic] United States |
PMID | 20406959
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Intramural)
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Copyright | Copyright (c) 2010 AACR |
Topics |
- Aged
- Aged, 80 and over
- Case-Control Studies
- Female
- Hodgkin Disease
(etiology, pathology)
- Humans
- Lymphoma, Non-Hodgkin
(etiology, pathology)
- Male
- Neoplasms, Plasma Cell
(etiology, pathology)
- Organ Transplantation
(adverse effects)
- Risk Factors
- SEER Program
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