Abstract | BACKGROUND:
Lactose intolerance resulting in gastrointestinal symptoms is a common health concern. Diagnosis and management of this condition remain unclear. PURPOSE: DATA SOURCES: Multiple electronic databases, including MEDLINE and the Cochrane Library, for trials published in English from 1967 through November 2009. STUDY SELECTION: DATA EXTRACTION: Three investigators independently reviewed articles, extracted data, and assessed study quality. DATA SYNTHESIS: 36 unique randomized studies (26 on lactase- or lactose-hydrolyzed milk supplements, lactose-reduced milk, or tolerable doses of lactose; 7 on probiotics; 2 on incremental lactose administration for colonic adaptation; and 1 on another agent) met inclusion criteria. Moderate-quality evidence indicated that 12 to 15 g of lactose (approximately 1 cup of milk) is well tolerated by most adults. Evidence was insufficient that lactose-reduced solution or milk with a lactose content of 0 to 2 g, compared with greater than 12 g, is effective in reducing symptoms of lactose intolerance. Evidence for probiotics, colonic adaptation, and other agents was also insufficient. LIMITATIONS: Most studies evaluated persons with lactose malabsorption rather than lactose intolerance. Variation in enrollment criteria, outcome reporting, and the composition and dosing of studied agents precluded pooling of results and limited interpretation. CONCLUSION:
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Authors | Aasma Shaukat, Michael D Levitt, Brent C Taylor, Roderick MacDonald, Tatyana A Shamliyan, Robert L Kane, Timothy J Wilt |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 152
Issue 12
Pg. 797-803
(Jun 15 2010)
ISSN: 1539-3704 [Electronic] United States |
PMID | 20404262
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review, Systematic Review)
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Chemical References |
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Topics |
- Biomedical Research
(trends)
- Dairy Products
- Dietary Supplements
- Feeding Behavior
- Forecasting
- Humans
- Lactase
(administration & dosage)
- Lactose
(administration & dosage)
- Lactose Intolerance
(epidemiology, prevention & control, therapy)
- Prevalence
- Probiotics
(therapeutic use)
- United States
(epidemiology)
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