Successful treatment of Darier's disease with adapalene gel.

Abstract

We report a 12-year-old Japanese boy with a 3-year history of skin lesions that had been unsuccessfully treated with topical steroids. We initiated two different topical treatments with adapalene gel 0.1% (Differin(®) Gel 0.1%) and high-concentration vitamin D3 (tacalcitol) ointment; the lesions treated with adapalene gel improved dramatically in the first 2 months, whereas the high-concentration vitamin D3 ointment resulted in little improvement. Topical adapalene gel 0.1% may be a promising choice as a topical treatment of Darier's disease because of its high efficiency and lack of adverse effects.

• Authors: Masatoshi Abe, Chizuru Inoue, Yoko Yokoyama, Osamu Ishikawa
• Journal: Pediatric dermatology (Pediatr Dermatol) 2011 Mar-Apr Vol. 28 Issue 2 Pg. 197-8 ISSN: 1525-1470 [Electronic] United States
• PMID: 20403120 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2010 Wiley Periodicals, Inc.

Chemical References

• Dermatologic Agents
• Gels
• Naphthalenes
• Adapalene

Topics

• Adapalene
• Administration, Topical
• Child
• Darier Disease (drug therapy, pathology)
• Dermatologic Agents (administration & dosage)
• Gels
• Humans
• Male
• Naphthalenes (administration & dosage)
• Treatment Outcome