Comparison between imipramine and imipramine combined with pseudoephedrine in 5-12-year-old children with uncomplicated enuresis: a double-blind clinical trial.

Abstract

OBJECTIVE:

Monosymptomatic nocturnal enuresis is a common entity, with a prevalence of 10% at the age of 7 years. For its primary treatment, we compared the effect of combination medical therapy (imipramine with pseudoephedrine) with imipramine alone.

MATERIALS AND METHODS:

In this one-center prospective double-blind clinical trial, 100 school-age children (age range 5-12 years) were enrolled. They were divided into two groups, comparable in terms of age and other demographic factors: (A) adjusted doses of a combination of imipramine with pseudoephedrine, and (B) imipramine with placebo were administered. Improvement was defined as less than 2 wet nights per week.

RESULTS:

Four weeks after drug withdrawal, the response rate was 74% in group A in comparison to 52% in group B, this difference being statistically significant. There was a recurrence of enuresis in both groups during the 4 weeks after treatment was discontinued (10% increase in group A and 8% increase in group B).

CONCLUSION:

The additive pharmacologic effects of imipramine with pseudoephedrine for the treatment of monosymptomatic nocturnal enuresis in children were well tolerated, and gave significantly faster results than single drug therapy using imipramine. The moderate-to-high recurrence rate following discontinuation of medical treatment indicates the need for a longer term study involving more cases.

• Authors: Mehdi Abedin Zadeh, Mohammad Kazem Moslemi, Golrasteh Kholaseh Zadeh
• Journal: Journal of pediatric urology (J Pediatr Urol) Vol. 7 Issue 1 Pg. 30-3 (Feb 2011) ISSN: 1873-4898 [Electronic] England
• PMID: 20399146 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Antidepressive Agents, Tricyclic
• Sympathomimetics
• Pseudoephedrine
• Imipramine

Topics

• Antidepressive Agents, Tricyclic (administration & dosage, adverse effects)
• Child
• Child, Preschool
• Double-Blind Method
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Humans
• Imipramine (administration & dosage, adverse effects)
• Male
• Nocturnal Enuresis (drug therapy)
• Prospective Studies
• Pseudoephedrine (administration & dosage, adverse effects)
• Recurrence
• Sympathomimetics (administration & dosage, adverse effects)
• Treatment Outcome