Abstract |
Lactate dehydrogenase (LDH) isoenzyme distribution was examined in 106 urine samples being tested cytologically for evidence of bladder cancer; the samples were selected to have less than 20 leucocytes and erythrocytes per high power field and the LDH pattern determined by electrophoresis. The Papanicolaou stained-smears showed 68 negative, 17 suspicious and 21 positive. The LDH M-fraction of the urinary supernatant in cytologically positive cases was significantly greater than in negative cases, although the latter included a few false negative samples. Some of the false negatives gave positive results for the LDH M-fraction; these results suggest that the determination of LDH isoenzymes in the urine is useful in diagnosing urinary tract cancers, including early stage, and for follow-up of patients with bladder cancers after surgical resection.
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Authors | A Nishikawa, T Tanaka, T Takeuchi, S Fujihiro, H Mori |
Journal | British journal of cancer
(Br J Cancer)
Vol. 63
Issue 5
Pg. 819-21
(May 1991)
ISSN: 0007-0920 [Print] England |
PMID | 2039708
(Publication Type: Journal Article)
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Chemical References |
- Isoenzymes
- L-Lactate Dehydrogenase
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Topics |
- Carcinoma, Transitional Cell
(diagnosis, urine)
- Clinical Enzyme Tests
- Humans
- Isoenzymes
- L-Lactate Dehydrogenase
(urine)
- Urinary Bladder Neoplasms
(diagnosis, urine)
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