Abstract | BACKGROUND: METHODS: After regulatory agency approval and informed consent, we examined the effect of 2.0 mg intrathecal ketorolac in 41 healthy volunteers to acute noxious thermal stimuli in normal skin and to mechanical stimuli in skin sensitized by topical capsaicin or ultraviolet burn. We also examined the effect of intravenous ketorolac. RESULTS: Intrathecal ketorolac reduced hypersensitivity when it was induced by a combination of ultraviolet burn plus intermittent heat and, according to one of the two analytical strategies, when it was induced by ultraviolet burn alone. CONCLUSIONS: These data suggest a more limited role for spinal cord cyclooxygenase in human pain states than predicted by studies in animals.
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Authors | James C Eisenach, Regina Curry, Chuanyao Tong, Timothy T Houle, Tony L Yaksh |
Journal | Anesthesiology
(Anesthesiology)
Vol. 112
Issue 5
Pg. 1216-24
(May 2010)
ISSN: 1528-1175 [Electronic] United States |
PMID | 20395821
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Capsaicin
(toxicity)
- Female
- Hot Temperature
(adverse effects)
- Humans
- Injections, Spinal
- Ketorolac
(administration & dosage)
- Male
- Middle Aged
- Pain
(chemically induced, drug therapy, etiology)
- Pain Measurement
(drug effects, methods)
- Physical Stimulation
(adverse effects)
- Ultraviolet Rays
(adverse effects)
- Young Adult
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