NREM sleep architecture and relation to GH/IGF-1 axis in Laron syndrome.

Abstract

BACKGROUND:

Laron syndrome (LS), known as growth hormone (GH) receptor deficiency, is a rare form of inherited GH resistance. Sleep disorders were described as a common feature of adult LS patients, while no data are available in children. Bi-directional interactions between human sleep and the somatotropic system were previously described, mainly between slow wave sleep and the nocturnal GH surge.

AIMS:

To analyze the sleep macro- and microstructure in LS and to evaluate the influence of substitutive insulin-like growth factor 1 (IGF-1) therapy on it.

METHODS:

Two young LS females underwent polysomnography; the first study was performed during IGF-1 therapy, the second one after a 3-month wash-out period.

RESULTS:

In both patients, the sleep macrostructure showed that time in bed, sleep period time, total sleep time, sleep efficiency and rapid eye movement (REM) percentage were all increased during wash-out. The sleep microstructure (cyclic alternating pattern: CAP) showed significantly higher EEG slow oscillations (A1%) in NREM sleep, both during IGF-1 therapy and wash-out.

CONCLUSIONS:

Sleep macrostructure in LS children is slightly affected by substitutive IGF-1 therapy. Sleep microstructure shows an increase of A1%, probably related to abnormally high hypothalamic GHRH secretion, due to GH insensitivity.

• Authors: Elisabetta Verrillo, Carla Bizzarri, Marco Cappa, Oliviero Bruni, Martino Pavone, Renato Cutrera
• Journal: Hormone research in paediatrics (Horm Res Paediatr) Vol. 73 Issue 5 Pg. 414-9 ( 2010) ISSN: 1663-2826 [Electronic] Switzerland
• PMID: 20389115 (Publication Type: Journal Article)
• Copyright: Copyright 2010 S. Karger AG, Basel.

Chemical References

• Human Growth Hormone
• Insulin-Like Growth Factor I

Topics

• Adolescent
• Child
• Female
• Human Growth Hormone (metabolism)
• Humans
• Insulin-Like Growth Factor I (adverse effects, therapeutic use)
• Laron Syndrome (drug therapy, physiopathology)
• Polysomnography
• Sleep (drug effects)
• Sleep Wake Disorders (etiology)