Abstract | BACKGROUND:
Laron syndrome (LS), known as growth hormone (GH) receptor deficiency, is a rare form of inherited GH resistance. Sleep disorders were described as a common feature of adult LS patients, while no data are available in children. Bi-directional interactions between human sleep and the somatotropic system were previously described, mainly between slow wave sleep and the nocturnal GH surge. AIMS: METHODS: Two young LS females underwent polysomnography; the first study was performed during IGF-1 therapy, the second one after a 3-month wash-out period. RESULTS: In both patients, the sleep macrostructure showed that time in bed, sleep period time, total sleep time, sleep efficiency and rapid eye movement (REM) percentage were all increased during wash-out. The sleep microstructure (cyclic alternating pattern: CAP) showed significantly higher EEG slow oscillations (A1%) in NREM sleep, both during IGF-1 therapy and wash-out. CONCLUSIONS: Sleep macrostructure in LS children is slightly affected by substitutive IGF-1 therapy. Sleep microstructure shows an increase of A1%, probably related to abnormally high hypothalamic GHRH secretion, due to GH insensitivity.
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Authors | Elisabetta Verrillo, Carla Bizzarri, Marco Cappa, Oliviero Bruni, Martino Pavone, Renato Cutrera |
Journal | Hormone research in paediatrics
(Horm Res Paediatr)
Vol. 73
Issue 5
Pg. 414-9
( 2010)
ISSN: 1663-2826 [Electronic] Switzerland |
PMID | 20389115
(Publication Type: Journal Article)
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Copyright | Copyright 2010 S. Karger AG, Basel. |
Chemical References |
- Human Growth Hormone
- Insulin-Like Growth Factor I
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Topics |
- Adolescent
- Child
- Female
- Human Growth Hormone
(metabolism)
- Humans
- Insulin-Like Growth Factor I
(adverse effects, therapeutic use)
- Laron Syndrome
(drug therapy, physiopathology)
- Polysomnography
- Sleep
(drug effects)
- Sleep Wake Disorders
(etiology)
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