A novel bioactive haemodialysis system using dissolved dihydrogen (H2) produced by water electrolysis: a clinical trial.

Abstract

BACKGROUND:

Chronic inflammation in haemodialysis (HD) patients indicates a poor prognosis. However, therapeutic approaches are limited. Hydrogen gas (H(2)) ameliorates oxidative and inflammatory injuries to organs in animal models. We developed an HD system using a dialysis solution with high levels of dissolved H(2) and examined the clinical effects.

METHODS:

Dialysis solution with H(2) (average of 48 ppb) was produced by mixing dialysate concentrates and reverse osmosis water containing dissolved H(2) generated by a water electrolysis technique. Subjects comprised 21 stable patients on standard HD who were switched to the test HD for 6 months at three sessions a week.

RESULTS:

During the study period, no adverse clinical signs or symptoms were observed. A significant decrease in systolic blood pressure (SBP) before and after dialysis was observed during the study, and a significant number of patients achieved SBP <140 mmHg after HD (baseline, 21%; 6 months, 62%; P < 0.05). Changes in dialysis parameters were minimal, while significant decreases in levels of plasma monocyte chemoattractant protein 1 (P < 0.01) and myeloperoxidase (P < 0.05) were identified.

CONCLUSIONS:

Adding H(2) to haemodialysis solutions ameliorated inflammatory reactions and improved BP control. This system could offer a novel therapeutic option for control of uraemia.

• Authors: Masaaki Nakayama, Hirofumi Nakano, Hiromi Hamada, Noritomo Itami, Ryoichi Nakazawa, Sadayoshi Ito
• Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (Nephrol Dial Transplant) Vol. 25 Issue 9 Pg. 3026-33 (Sep 2010) ISSN: 1460-2385 [Electronic] England
• PMID: 20388631 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)

Chemical References

• Hemodialysis Solutions
• Water
• Hydrogen

Topics

• Aged
• Blood Pressure
• Electrolysis
• Female
• Hemodialysis Solutions
• Humans
• Hydrogen (chemistry)
• Kidney Failure, Chronic (blood, therapy)
• Male
• Renal Dialysis (instrumentation, methods)
• Water (chemistry)