Abstract | BACKGROUND: Mass vaccination is the principal preventive measure against a smallpox outbreak after an act of bioterrorism. Vaccination of subjects who received immunosuppressive therapies is problematic because of smallpox vaccine reactogenicity. Moreover, long-term immunity to vaccinia might be affected. OBJECTIVE: The objective of the study was to examine the effect of cytotoxic chemotherapy on long-term immunity to vaccinia. METHODS: RESULTS: CONCLUSIONS: Immunity to smallpox is reduced after receipt of chemotherapy for breast cancer. This finding should be considered when planning smallpox vaccination campaigns. The effect of immunosuppressive treatments on persistence of immunity should be tested with respect to additional vaccines or natural infections.
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Authors | Itay Wiser, Nadav Orr, Bella Kaufman, Shlomo Segev, Zehava Smetana, Ania Bialik, Nava Epstein, Ella Mendelson, Raphael Catane, Dani Cohen |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 201
Issue 10
Pg. 1527-34
(May 15 2010)
ISSN: 1537-6613 [Electronic] United States |
PMID | 20388035
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Viral
- Antineoplastic Agents
- Immunoglobulin G
- Immunosuppressive Agents
- Smallpox Vaccine
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Topics |
- Adult
- Aged
- Antibodies, Viral
(blood)
- Antineoplastic Agents
(pharmacology)
- Breast Neoplasms
(drug therapy)
- Case-Control Studies
- Female
- Humans
- Immunoglobulin G
(blood, classification)
- Immunosuppressive Agents
(pharmacology)
- Middle Aged
- Retrospective Studies
- Smallpox
(immunology, virology)
- Smallpox Vaccine
(immunology)
- Vaccinia virus
(immunology)
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