Abstract | OBJECTIVES: METHODS: RESULTS: There were statistically significant differences between cyclin D1 expression in odontogenic keratocysts and radicular cysts (p=0.001) and ameloblastomas (p=0.04). The differences in CEA expression between the four studied lesions were statistically significant (p<0.0005). Proliferating cells were significantly more prevalent in odontogenic keratocysts (p<0.0005) with a mean percentage of Ki-67 positively stained nuclei of 40%. In dentigerous cysts this mean was of 17%, of 15.5% in RC and of 7.8 in ameloblastomas. CONCLUSION: Some of these findings could support the theory that odontogenic keratocysts are neoplastic in origin, but other results clearly support that these lesions are developmental cysts with some neoplastic properties because of the high intrinsic growth potential.
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Authors | Juan-Carlos de Vicente, Aintzane Torre-Iturraspe, Ana-María Gutiérrez, Paloma Lequerica-Fernández |
Journal | Medicina oral, patologia oral y cirugia bucal
(Med Oral Patol Oral Cir Bucal)
Vol. 15
Issue 5
Pg. e709-15
(Sep 01 2010)
ISSN: 1698-6946 [Electronic] Spain |
PMID | 20383104
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Humans
- Immunohistochemistry
- Odontogenic Cysts
(chemistry, pathology)
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