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Association between lipodystrophy and leptin in human immunodeficiency virus-1-infected children receiving lopinavir/ritonavir-based therapy.

Abstract
Highly active antiretroviral therapy might lead to the development of dyslipidemia and lipodystrophy (LD) syndrome. We carried out a multicenter prospective study of 22 human immunodeficiency virus (HIV)-1-infected children treated during 48 months with lopinavir/ritonavir-based highly active antiretroviral therapy to evaluate the trend of serum lipids and adipokines. Increase in plasma leptin levels and leptin/adiponectin ratio was associated with LD. These adipokines may be surrogate markers of LD.
AuthorsSalvador Resino, Claudia Palladino, Raquel Lorente, Dariela Micheloud, Jose Maria Bellón, Beatriz Larru, Maria Dolores Gurbindo Gutiérrez, Maria Isabel de José, Rosa Polo, Maria Angeles Muñoz-Fernández, Spanish Group of Pediatric HIV Infection
JournalThe Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 29 Issue 8 Pg. 774-7 (Aug 2010) ISSN: 1532-0987 [Electronic] United States
PMID20375850 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-HIV Agents
  • Biomarkers
  • Leptin
  • Pyrimidinones
  • Lopinavir
  • Ritonavir
Topics
  • Adolescent
  • Anti-HIV Agents (adverse effects, therapeutic use)
  • Antiretroviral Therapy, Highly Active (methods)
  • Biomarkers
  • Child
  • Child, Preschool
  • HIV Infections (complications, drug therapy)
  • HIV-1
  • HIV-Associated Lipodystrophy Syndrome (chemically induced)
  • Humans
  • Infant
  • Leptin (blood)
  • Lopinavir
  • Prospective Studies
  • Pyrimidinones (adverse effects, therapeutic use)
  • Ritonavir (adverse effects, therapeutic use)

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