Abstract | BACKGROUND: METHODS: We included 43 consecutive patients with anterior-circulation ischemia who underwent MRI studies before and after thrombolysis. Each hemorrhage was classified as a hemorrhagic infarction (HI) or parenchymal hemorrhage (PH) according to the European Cooperative Acute Stroke Study definition. The clinical outcome was defined as an improvement (> or =4-point reduction) or deterioration (> or =4-point increase) based on a comparison between the initial and the 30-day NIHSS scores. RESULTS: The incidence of ICHs was 58%, and the HI rate was 52%; both were higher than the rates reported in the literature. Most of the patients with HI improved clinically, and these patients had second MRAs that showed recanalization. None of the patients with PH demonstrated improvement. CONCLUSIONS: Three-tesla MRI may reveal a higher frequency of HI type hemorrhages than lower-field MRIs, and HI may be a predictor of good recovery by reflecting the presence of recanalization. The rate of PH in our study was low compared to other studies, probably due to the lower dosage of rt-PA.
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Authors | Masafumi Harada, Naomi Morita, Masaaki Uno, Junichiro Satomi, Yuishin Izumi, Kotaro Asanuma, Hiromu Nishitani, Ryuuji Kaji, Shinji Nagahiro |
Journal | Cerebrovascular diseases (Basel, Switzerland)
(Cerebrovasc Dis)
Vol. 29
Issue 6
Pg. 571-5
( 2010)
ISSN: 1421-9786 [Electronic] Switzerland |
PMID | 20375500
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2010 S. Karger AG, Basel. |
Chemical References |
- Recombinant Proteins
- Tissue Plasminogen Activator
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Topics |
- Acute Disease
- Aged
- Brain
(pathology)
- Brain Ischemia
(complications)
- Cerebral Hemorrhage
(epidemiology, etiology, pathology)
- Diffusion Magnetic Resonance Imaging
- Echo-Planar Imaging
(methods)
- Female
- Humans
- Image Processing, Computer-Assisted
- Injections, Intravenous
- Male
- Middle Aged
- Recombinant Proteins
- Stroke
(complications, drug therapy, etiology)
- Thrombolytic Therapy
(adverse effects)
- Tissue Plasminogen Activator
(adverse effects, therapeutic use)
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