Abstract |
In this study we have reported that bergapten (B) and bergapten plus UV (PUVA) are able to significantly affect MCF-7, ZR-75 and SKBR-3 breast cancer cell proliferations. B induced a lowering of PI3K/AKT survival signal in MCF-7 cells even in presence of IGF-I stimulation. Furthermore, B and in a higher extent, PUVA up-regulated the p53 mRNA and the protein content. An increased co-association between p21 WAF and proliferating cell nuclear antigen ( PCNA) has been observed in PUVA-treated MCF-7 cells, thus inhibiting DNA replication. These results highlight how B, and its photoactivated compound, exert antiproliferative effects and induce apoptotic responses in breast cancer cells.
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Authors | Maria Luisa Panno, Francesca Giordano, Fabrizia Mastroianni, M Grazia Palma, Viviana Bartella, Amalia Carpino, Saveria Aquila, Sebastiano Andò |
Journal | FEBS letters
(FEBS Lett)
Vol. 584
Issue 11
Pg. 2321-6
(Jun 03 2010)
ISSN: 1873-3468 [Electronic] England |
PMID | 20371365
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Photosensitizing Agents
- Proliferating Cell Nuclear Antigen
- Tumor Suppressor Protein p53
- 5-Methoxypsoralen
- Insulin-Like Growth Factor I
- Proto-Oncogene Proteins c-akt
- Methoxsalen
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Topics |
- 5-Methoxypsoralen
- Breast Neoplasms
(drug therapy, genetics)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Humans
- Insulin-Like Growth Factor I
(pharmacology)
- Methoxsalen
(analogs & derivatives, pharmacology)
- Photosensitizing Agents
(pharmacology)
- Proliferating Cell Nuclear Antigen
(metabolism)
- Proto-Oncogene Proteins c-akt
(metabolism)
- Radiation
- Signal Transduction
(drug effects)
- Tumor Suppressor Protein p53
(metabolism)
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